Antigone Man-slayer
Last Updated: August 18, 2026
Antigone Man-slayer Overview
Antigone Man-slayer is the fusion epic for The Cowardly Lion‘s mixed fusion event in RAID: Shadow Legends, arriving alongside (but not part of) the Echoes of Oz event. From her name you might expect her to be good against male characters, or to do a lot of damage; neither of these things is true.
Antigone is actually a good support champion against debuff-heavy bosses who place Poisons or HP Burns, since she can Remove them all from your team and then Transfer them back to the bosses: she’s particularly good against Spider, Nether Spider, and both normal and hard difficulty Dragon. This move can easily fill a boss’s entire debuff bar (a target can have 10 debuffs maximum) with Poisons, though it’s less useful with HP Burn since it cannot stack. Since she only Removes one additional random debuff, she’s not the best general Debuff Remover.
Her A2 and A1 brings some general utility as well: a void-affinity AoE Weaken is useful, and her Shields and Healing are good too by epic standards.
All in all, she’s a decent epic support champion but she’s very much tied into countering specific Poison-heavy bosses if we’re being totally honest. Not a terrible consolation prize for new players who cannot manage to complete the whole Cowardly Lion fusion, but not really worth hunting for an extra copy and absolutely not worth skipping him for.
Antigone Man-slayer Skills

8/10
Book Value
Book Priority
Antigone Man-slayer PVE Masteries




![Shield Breaker - Increases damage inflicted to targets under [Shield], buffs by 25% shield-breaker](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/shield-breaker.png)








![Opportunist - Increases damage inflicted to targets with [Stun], [Sleep], [Fear], [True Fear], [Freeze], [Petrification], debuffs by 12%. opportunist](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/opportunist.png)


![Blood Shield - Places a [Shield], buff on this Champion for 1 turn when this Champion kills an enemy. The value of the [Shield], is equal to 15% of this Champion's MAX HP. Occurs once per turn blood-shield](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/blood-shield.png)








![Rejuvenation - Increases the amount of healing and the value of [Shield], buffs this Champion receives by 5% rejuvenation](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/rejuvenation.png)
![Mighty Endurance - Decreases the damage received by 10% if this Champion has [Stun], [Sleep], [Fear], [True Fear], [Freeze], [Petrification], debuffs. might-endurance](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/might-endurance.png)




![Wisdom of Battle - Has a 30% chance of placing a [Block Debuffs], buff on this Champion for 1 turn when [Stun], [Sleep], [Fear], [True Fear], [Freeze], [Petrification], debuffs expire on this Champion. wisdom-of-battle](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/wisdom-of-battle.png)


![Harvest Despair - Has a 60% chance of placing a [Leech], debuff for 1 turn when placing [Stun], [Sleep], [Fear], [True Fear], [Freeze], [Petrification], debuffs. harvest-despair](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/harvest-despair.png)




![Deterrence - Has a 20% chance to counterattack an enemy when they apply a [Stun], [Sleep], [Fear], [True Fear], [Freeze], [Petrification], debuff on an ally. Cooldown: 1 turn deterrence](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/deterrence.png)


![Fearsome Presence - Increases the chances of placing a [Stun], [Sleep], [Freeze], [Fear], [True Fear], [Provoke], or [Sheep], debuff from Skills or Artifacts by 5% fearsome-presence](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/fearsome-presence.png)




![Shieldbearer - Increases the value of [Shield], buffs this Champion casts by 5% shieldbearer](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/shieldbearer.png)


![Healing Savior - Increases the amount of healing and the value of [Shield], buffs placed by this Champion by 10% if the target ally has 40% HP or less healing-savior](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/healing-savior.png)



![Merciful Aid - Increases the amount of healing and the value of [Shield], buffs placed by this Champion by 15% if the target ally has [Stun], [Sleep], [Fear], [True Fear], or [Freeze] debuffs merciful-aid](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/merciful-aid.png)



![Lasting Gifts - Has a 30% chance to extend the duration of any buff cast by this Champion by 1 turn.
It will not extend [Block Damage], [Unkillable], or [Revive on Death], buffs. lasting-gifts](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/lasting-gifts.png)

![Sniper - Increases the chances of placing any debuff from Skills or Artifacts by 5%.
It will not increase the chances of placing [Stun], [Sleep], [Freeze], [Fear], [True Fear], [Provoke], or [Petrification], debuffs. sniper](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/sniper.png)
![Master Hexer - Has a 30% chance to extend the duration of any debuff cast by this Champion by 1 turn. It will not extend [Stun], [Sleep], [Freeze], [Provoke], [Fear], [True Fear], [Bomb], or [Petrification], debuffs. master-hexer](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/master-hexer.png)




Antigone Man-slayer PVP Masteries




![Shield Breaker - Increases damage inflicted to targets under [Shield], buffs by 25% shield-breaker](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/shield-breaker.png)








![Opportunist - Increases damage inflicted to targets with [Stun], [Sleep], [Fear], [True Fear], [Freeze], [Petrification], debuffs by 12%. opportunist](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/opportunist.png)


![Blood Shield - Places a [Shield], buff on this Champion for 1 turn when this Champion kills an enemy. The value of the [Shield], is equal to 15% of this Champion's MAX HP. Occurs once per turn blood-shield](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/blood-shield.png)








![Rejuvenation - Increases the amount of healing and the value of [Shield], buffs this Champion receives by 5% rejuvenation](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/rejuvenation.png)
![Mighty Endurance - Decreases the damage received by 10% if this Champion has [Stun], [Sleep], [Fear], [True Fear], [Freeze], [Petrification], debuffs. might-endurance](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/might-endurance.png)




![Wisdom of Battle - Has a 30% chance of placing a [Block Debuffs], buff on this Champion for 1 turn when [Stun], [Sleep], [Fear], [True Fear], [Freeze], [Petrification], debuffs expire on this Champion. wisdom-of-battle](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/wisdom-of-battle.png)


![Harvest Despair - Has a 60% chance of placing a [Leech], debuff for 1 turn when placing [Stun], [Sleep], [Fear], [True Fear], [Freeze], [Petrification], debuffs. harvest-despair](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/harvest-despair.png)




![Deterrence - Has a 20% chance to counterattack an enemy when they apply a [Stun], [Sleep], [Fear], [True Fear], [Freeze], [Petrification], debuff on an ally. Cooldown: 1 turn deterrence](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/deterrence.png)


![Fearsome Presence - Increases the chances of placing a [Stun], [Sleep], [Freeze], [Fear], [True Fear], [Provoke], or [Sheep], debuff from Skills or Artifacts by 5% fearsome-presence](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/fearsome-presence.png)




![Shieldbearer - Increases the value of [Shield], buffs this Champion casts by 5% shieldbearer](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/shieldbearer.png)


![Healing Savior - Increases the amount of healing and the value of [Shield], buffs placed by this Champion by 10% if the target ally has 40% HP or less healing-savior](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/healing-savior.png)



![Merciful Aid - Increases the amount of healing and the value of [Shield], buffs placed by this Champion by 15% if the target ally has [Stun], [Sleep], [Fear], [True Fear], or [Freeze] debuffs merciful-aid](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/merciful-aid.png)



![Lasting Gifts - Has a 30% chance to extend the duration of any buff cast by this Champion by 1 turn.
It will not extend [Block Damage], [Unkillable], or [Revive on Death], buffs. lasting-gifts](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/lasting-gifts.png)

![Sniper - Increases the chances of placing any debuff from Skills or Artifacts by 5%.
It will not increase the chances of placing [Stun], [Sleep], [Freeze], [Fear], [True Fear], [Provoke], or [Petrification], debuffs. sniper](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/sniper.png)
![Master Hexer - Has a 30% chance to extend the duration of any debuff cast by this Champion by 1 turn. It will not extend [Stun], [Sleep], [Freeze], [Provoke], [Fear], [True Fear], [Bomb], or [Petrification], debuffs. master-hexer](https://hellhades.com/wp-content/plugins/rsl-assets/assets/masteries/master-hexer.png)




Dungeon and Boss Blessings
Antigone Man-slayer Relics
Antigone Man-slayer Gear Recommendations
Recommended PVE Stats
ACC (priority 1★★★): Early-game = 200+; Mid-game = 350+; Late-game = 500+
SPD (priority 2★★): Early-game = 250+; Mid-game = 300+; Late-game = 350+
HP(priority 2★★): Early-game = 40000+; Mid-game = 60000+; Late-game = 80000+
RES (priority 3★): Early-game = 300+; Mid-game = 400+; Late-game = 500+
Recommended PVE Artifact Sets
BEGINNER
Speed: boosts the SPD stat.
Accuracy: boosts the ACC stat.
Perception: accessible option which gives both ACC and SPD stats.
ADVANCED
Pinpoint: flexible; good for a 2-set accessory SPD boost.
Regeneration (★HH team pick): provides substantial self-healing.
Guardian: provides self-healing and team damage reduction.
Shield: protects you team with a Shield at the start of each round.
Feral: flexible version of Perception, with added bonus damage at 9-piece.
SITUATIONAL
Stoneskin: Strong defensive set, particularly at 4-pieces.
Mercurial: Best defensive set, particularly strong at 9-pieces.
Recommended PVP Stats
ACC (priority 1★★★): Early-game = 200+; Mid-game = 350+; Late-game = 500+
SPD (priority 2★★): Early-game = 250+; Mid-game = 300+; Late-game = 350+
HP(priority 2★★): Early-game = 40000+; Mid-game = 60000+; Late-game = 80000+
RES (priority 3★): Early-game = 300+; Mid-game = 500+; Late-game = 700+
Recommended PVP Artifact Sets
BEGINNER
Speed: boosts the SPD stat.
Accuracy: boosts the ACC stat.
Perception: accessible option which gives both ACC and SPD stats.
ADVANCED
Pinpoint: flexible; good for a 2-set accessory SPD boost.
Shield: protects you team with a Shield at the start of each round.
Stoneskin: Strong defensive set, particularly at 4-pieces.
Feral: flexible version of Perception, with added bonus damage at 9-piece.
Mercurial (★HH team pick): Best defensive set, particularly strong at 9-pieces.





