How to Beat St Hermeida in Void Hunters Open Alpha

If you thought Prisoner was tough, then buckle up because the dial is turned up again in the final campaign fight in Void Hunters. St Hermeida is the kind of encounter that punishes sloppy timing and the wrong unit choices at the same time. Whilst trying to brute force it “can” work, there is a good chance your team just gets flattened.

The good news is that this fight is absolutely beatable, and my three runs highlight something really important about the encounter. There is not just one answer. You can clear St Hermeida with an aggressive burst strategy, or you can grind the boss down with control, blinds, and the right support pairing. If you understand what actually makes the fight dangerous, the whole battle starts to make a lot more sense.

Here is the full breakdown of the St Hermeida fight, including the key mechanics, the standout units in my runs, and the strategies that made the clears possible.

The biggest reason this fight causes problems is that St Hermeida heavily punishes debuffed targets. If your team has any in the final wave, the boss can unleash a massive nuke that quickly ends the run. She also places them herself and reduces your turn meter which makes it even harder.  So half the the fight is about preparation as much as it is damage.

One of the most important details from playing the alpha is that buffs persist between waves. That changes how you need to think about the battle. Instead of only reacting to the boss when you reach the final stage, you should already be setting up during the previous wave. Debuff immunity, cleanses, cooldown management, and even when you choose to use certain support skills can decide whether the final wave is manageable or whether you get your cheeks clapped.

There is also another hidden surprise that most dont realise. If you are going for a burst strategy and deal too much damage in one hit (40% of targets HP or more), the enemy Lamassu will place taunt, which disrupts your ability to focus St Hermeida. That mechanic is especially important, because it can derail your run at the exact moment you are trying to finish the boss.

So the fight asks three things from you. Can you avoid or cleanse debuffs? And can you either burst St Hermeida down fast enough or control the fight long enough to survive the nuke windows?

The biggest takeaway from all 3 of my runs is simple.

Before entering the St Hermeida stage, I deliberately held cooldowns and avoided unnecessary skill usage to make sure I had the what I needed when I needed it. Where possible this included trying to carry debuff immunity into the boss wave so the team would not immediately crumble if St Hermeida was faster than me.

This is where players can easily throw the run away. It is tempting to just auto through once your team becomes strong enough, but for this fight, that is dangerous. The third wave in particular still matters because you need to leave it with the right tools ready. I deliberately stalled the runs to make sure I was saving powerful abilities and only finishing the wave when the setup looked good.

This approach makes the boss much more manageable. Instead of reacting after the damage starts, you prevent the problem before it begins.

If there is one unit that comes up again and again in these clears, it is Nathaniel. He is one of the most important answers to the fight because he brings exactly what the boss punishes you for lacking.

The key value is his ability to provide debuff immunity. Yes he has Bless too but having the immunity is crucial. In my first clear, the whole idea was to apply immunity on the wave before the boss so the team entered the final phase protected. That was huge because it completely negated any turn order problems and gave me breathing room even when St Hermeida used her turn meter pushback.

Nathaniel also became even more important in the Holy Order clear because of his synergy tools. Once upgraded his skill 2 gives Holy Order allies retribution (counterattack) and his vow effect give Holy Order allies the ability to assist (team attack) whenever he uses a skill. In the Holy Order set up, the strategy was not about one huge damage dealer carrying the fight. It was a  strategy focused on grinding out the encounter through a series of continuous repeated team attacks, giving more opportunities for utility effects to land.

In other words, Nathaniel is an enbaler. He is not a typical “support”  so was not there to keep the team alive. But his utility is unmatched, whether its allowing your nuker to avoid debuffs and do their thing or whether he is helping a slow value team, turn into a functioning boss-kill setup.

One of the most interesting takeaways for me was how strongly Besemin performed. Initially slept on (and still is to some people) she came in clutch multiple times, and it is easy to see why. Blind is a huge part of surviving this encounter (and any boss for that matter).

In the runs, Besemin helped secure control over dangerous enemies through repeated blind application. In the Holy Order run, she became even more important because the strategy leaned heavily on keeping enemies, and eventually St Hermeida herself, under blind so we could churn out the damage slowly whilst easing the pressure on my supports.

Blind is OP because when the St Hermeida’s (or anyones) big attack comes out, it blows past you as if nothing ever happened. In one of the videos you can see this in effect when the boss’s nuke essentially fizzled because blind was active. That is what wins runs.

Besemin also scales well with Nathaniel’s support package. If the team is counterattacking more often and assisting more often, that means more chances for her basic attack to trigger and more chances for blind to stick. It turns a single debuff into the backbone of the whole strategy. She may not look like the obvious carry at first glance, but in this fight she was one of the most impactful units on the field.

You dont have Besemin? Not a problem, Vilk can also perform a similar role but timing becomes even more important. Due to his blind being on his second ability and not basic, you have to time it just right. However, when done right it makes things so much easier for you. He is also seasoned so matches perfectly for one of the star requirements.

The key thing is there are two different paths to victory.

The first is the burst strategy. This approach focuses on blowing up St Hermeida before the fight gets out of hand. In my run I used units like Reed and Angelo for heavy damage in one clear and Reed and Leo in the Seasoned-only version. Leo was particularly important because of his Hunted debuff, which allowed targeting to bypass taunters. That solved one of the boss fight’s most frustrating mechanics. Instead of getting forced to hit Lamassu, you could keep pressure on St Hermeida when it mattered.

The second is the slow, grindy strategy, which shined in the Holy Order clear. This run did not rely on a true hard carry damage dealer. Instead, it used a slower team with Nathaniel, Besemin, Lysadorea, Nadia, and Faustus. The damage was lower, but the team made up for it with survivability, repeated attacks, blinds, assist triggers, and careful buff timing.

Burst is faster and cleaner when it works, but requires manual play. The Holy Order version is slower, but much more auto friendly. Both can clear the encounter.

That is actually encouraging for players. It means St Hermeida is tough, but not locked behind one exact team. You need the right answers, not necessarily the exact same roster.

Several other names deserve credit here as part of the successful clears.

Reed was a major damage source and helped clean up waves before the boss. His ability to hit hard and take extra actions helped keep momentum high. Angelo also contributed to my first clear for his burst, between the two of them they made light work of the boss herself. Lilith is another useful answer because of her ability to cleanse and support the anti-debuff plan. She is also free so if you dont have Nathaniel dont panic, you can use Lilith but you MUST make sure you take 3 vials into the St Hermeida wave (4th one). So when Misfortune is placed on you, you can cleanse it off and heal, which should leave you surviving the first nuke of St Hermeida.

For the Holy Order team, Lysadorea played a valuable support role alongside Nathaniel, especially as the only recognised “Healer”. She also keeps Void Touch off which is nice. Faustus functioned as the practical damage option despite not being technically being one. His buff strip is also useful for the Taunt if it was ever applied. Nadia helped anchor the lineup as a tank, letting the slower strategy hold together long enough to win.

And then there is Leo, who may be one of the smartest picks for the encounter if you are using a Seasoned roster. His Hunted debuff neatly answers the taunt issue that can otherwise ruin a burst run. That single interaction made him one of the standout tech choices.

The St Hermeida fight in Void Hunters is one of those battles that teaches you how the game really works. It is not just about raw stats, it forces you to think and be creative. As players you have to consider buff timing, debuff prevention, and knowing exactly why your team is failing.

If you are stuck, start by fixing the basics. Bring debuff immunity or cleanse. Respect the boss nuke. And if your burst plan keeps getting interrupted, look for tools like Leo’s Hunted or lean into a slower blind-based strategy with units like Bessamin and Vilk.

That is the real lesson here. St Hermeida is brutal, but she is not unbeatable. Once you understand the fight, it stops feeling unfair and starts feeling like a proper boss encounter.